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- Original Article
- Significance of Acute Phase Reactants(APR) Score for the Early Detection of Neonatal Bacterial Infection
- Seong Woo Kim, Myung Ho Oh, Kee Hyuk Kim, Jay G. Sim
- Clin Exp Pediatr. 1998;41(11):1491-1497. Published online November 15, 1998
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Purpose : We performed acute phase reactants(APR) test to evaluate as an appropriate screening test for the early detection of neonatal bacterial infection. Methods : We selected 174 neonates and divided into two groups; sepsis group and well-baby group. We performed APR test. Results : There are no significant difference in total leukocyte count, immature to mature rentrophil ratio, toxic granules, and... -
- Clinical and Pathological Comparison of Neonatal Hepatitis and Extrahepatic Biliary Atresia in Korean Children
- Jae Hong Park, Ju Suk Lee, Su Eun Park, Chang Hun Lee
- Clin Exp Pediatr. 1998;41(10):1372-1379. Published online October 15, 1998
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Purpose : Neonatal hepatitis and congenital extrahepatic biliary atresia are two major causes of neonatal cholestasis. But the method of therapeutic trials used for each disease is essentially different. Nonetheless, it is very difficult to differentiate these diseases clinically and histologically. This study is aimed to find out major differences between the two by clinical characteristics and scoring of various... -
- Prognostic Factors for Mortality in Neonates with Respiratory Distress Syndrome After Surfactant Replacement Therapy
- Nam Soo Kang, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
- Clin Exp Pediatr. 1998;41(9):1188-1197. Published online September 15, 1998
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Purpose : To evaluate the association between neonatal mortality and the initial response to surfactant replacement therapy, and to examine the correlation between the response type and other prognostic factors. Methods : Sixty-seven neonates with respiratory distress syndrome(RDS) were divided into two groups; group I(n=51) who survived and group II(n=16) who died within the first 28 days of life after one... -
- C-Reactive Protein and Duration of Antibiotic Therapy in Neonatal Bacterial Infection
- Jae Il Yoo, Jin Hwa Jeong, Jeong Ho Lee, Jong Dae Cho
- Clin Exp Pediatr. 1998;41(7):901-908. Published online July 15, 1998
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Purpose : To determine whether C-reactive protein(CRP) can be used as a parameter to assess the safety of discontinuing antibiotic therapy and allows a shorter course of therapy in neonates treated for suspected bacterial infection. Methods : We have experienced 193 cases of suspected neonatal bacterial infection at Pusan Maryknoll Hospital. CRP levels were measured daily by immunonephelometry. Infants with initial... -
- Compatibility of Neonatal Parenteral Nutrient Solutions with Commonly Used Drugs during Y-site Delivery in NICU
- Ju Hun Choi, Kyong Ju Jeong, Ha Ryung Cho, Dong Soo Yim, Seung Ki Choi, Kyu Hyung Lee
- Clin Exp Pediatr. 1998;41(7):893-900. Published online July 15, 1998
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Purpose : Because vascular access sites in neonates are limited, intravenous(IV) medications must often be mixed with maintenance fluids, including parenteral nutrient(PN) solutions. This study was done to determine whether IV medications commonly prescribed in the neonatal in- tensive care unit(NICU) are compatible with the two neonatal PN solutions. Methods : The compatibility of neonatal PN solutions and selected other drugs... -
- Case Report
- A Case of Neonatal Hyperthyroidism with Unilateral Ear Anomaly
- Kwang Ok Chung, Na Yeon Kim, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
- Clin Exp Pediatr. 1998;41(6):845-849. Published online June 15, 1998
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Neonatal hyperthyroidism is a very rare disorder occurring typically in the offspring of patients with Graves' disease or chronic thyroiditis. It is caused by the transplacental passage of thyroid stimulating antibodies(TSAb) from the mother to the fetus. There has been few reports of neonatal hyperthyroidism associated with congenital anomalies. We experienced a case of neonatal hyperthyroidism with unilateral microtia and agenesis of external auditory canal... -
- Original Article
- Effect of Oral Administration of Cholestylamine with Phototherapy in the Treatment of Neonatal Hyperbilirubinemia
- Myung Ho O, Jay Gun Sim, Kee Hyuck Kim
- Clin Exp Pediatr. 1998;41(6):741-746. Published online June 15, 1998
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Purpose : Cholestylamine has been shown to release chloride ion and absorbs bile acid in the intestine, forming a nonabsorbable complex preventing enterohepatic circulation. The purpose of this study is to clarify the value of cholestylamine and the adequate dosage, in combination with phototherapy, as well as to confirm whether it shorten the duration of hospitalization. Methods : Total 80 full-term neonates with a... -
- Retrospective 3-year Clinical Study of Enterobacter Bacteremia in Neonatal Intensive Care Unit
- Kwang Ok Chung, Chun Hyuk Chang, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
- Clin Exp Pediatr. 1998;41(4):466-471. Published online April 15, 1998
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Purpose : Enterobacter is one of the important organisms in neonatal intensive care unit. We reviewed the clinical characteristics, underlying diseases, invasive procedures during admission, mortality and antibiotic sensitivity of Enterobacter infection in NICU. Methods : We retrospectively reviewed 21 neonatal patients whose blood cultures yielded Enterobacter between June 1994 and June 1997 at Dongguk University Hospital. Results : Blood cultures were positive in 62... -
- The Efficacy of Fetal Ultrasonography and Postnatal Abdominal Ultrasonography for the Diagnosis of Neonatal Abdominal Mass
- Hee Eun Lee, Ee Kyung Kim, Hee Seok Kim, Yun Kyoung Lee, Chan Hwu Park, Kyung Ran Park, June Dong Park, Beyong Il Kim, Woong Heum Kim, Jung Hwan Choi, Gui Won Park, Hwang Choi, Yong Choi, Chong Ku Yun
- Clin Exp Pediatr. 1998;41(3):299-306. Published online March 15, 1998
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Purpose : Most neonatal abdominal masses are benign in nature, but early detection and management is important to avoid the development of complications. So, we studied the causes of neonatal abdominal masses and the efficacy of ultrasonography for early detection and diagnosis. Methods : We reviewed 36 newborn infants with abdominal masses who had been admitted to the nursery and Neonatal... -
- Diurnal Variation in Serum Bilirubin Concentration of Normal Newborn Infant
- Cheol Am Kim, Jin Geong Jeong, Eui Tak Oh, Hong Ja Gang, Gil Seu Kim
- Clin Exp Pediatr. 1998;41(1):33-37. Published online January 15, 1998
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Purpose : We investigated whether there are independent intradaily changes in bilirubin levels in normal neonates. Methods : During the period of January 1996 till July 1996, 100 healthy newborn infants were studied for at least 3 consecutive days. Starting from the third day of life, consistent intradaily changes of bilirubin concentration were observed. And obstetric history, birth history, weight change at 3 days were... -
- The Significance of Increased Circulating Intercellular Adhesion Molecule 1(cICAM-1) in Neonatal Sepsis
- Hai Lee Chung, Eun Jung Park, Young Ho An, Jin Bok Hwang, Chang Ho Han, Young Dae Kwon, Sang Gyoung Kim
- Clin Exp Pediatr. 1997;40(12):1651-1659. Published online December 15, 1997
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Purpose : The early and efficient diagnosis of neonatal sepsis still remains a difficult task. Reliable laboratory test is not available yet and treatment is mainly based on the physical appearance of infants. And high number of negative blood cultures in cases of clinically diagnosed sepsis further emphasize the need for a more reliable index for early diagnosis. Intercellular adhesion molecule 1(ICAM-1) has been... -
- The Pathophysiology of the Transient Neonatal Tricuspid Regurgitation
- Dong-Chul Park, Churl-Young Chung, Seauck-Joong Yoon
- Clin Exp Pediatr. 1997;40(8):1131-1140. Published online August 15, 1997
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Purpose : This study was carried out to evaluate the role of the septal leaflet of the tricuspid valve. The hypothesis was that the neonatal tricuspid regurgitation(TR) was related to a transient elevation of right ventricular pressure in the neonatal period, that deviated ventricular septum and pull the anchored septal leaflet of the tricuspid valve. The pulled septal leaflet created the incomplete coaptation between... -
- Oral Agar and Conventional Phototherapy Combination in the Treament of Neonatal Hyperbilirubinemia
- Seong Wha Kim, Ji Hyang Doh, Jin Woo Choi, Min Hyang Kim, Ji Won Lee, Sung Taek Kim
- Clin Exp Pediatr. 1997;40(7):931-938. Published online July 15, 1997
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Purpose : Neonatal jaundice is one of the most common problems in our country leading to hospitalization. Agar is low cost, low risk, and easily fed orally; it can bind bilirubin in the intestine, decreasing its enterohepatic circulation, thereby decreasing serum bilirubin levels. At present, however, the effectiveness of agar in the prevention and treament of neonatal jaundice is quite conflicting and controversy. Recently we... -
- Erratum
- A Case of Joubert Syndrome
- Hye-Young Kim, Sun-Jun Kim, Jung-Soo Kim
- Accepted January 1, 1970
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Joubert syndrome is frequently associated with developmental delay and mental retardation, neonatal tachypnea and apnea, abnormal eye movements, and ataxia. It is inherited by an autosomal recessive trait. The most significant and constant neuropathological finding is partial or total agenesis of cerebellar vermis. Absence of the vermis results in a triangular-shaped mid-fourth ventricle and a "bat-wing" shaped fourth ventricle superiorly. The superior cerebellar peduncles... -
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- Original Article
- Clinical Study of Symptoms and Various Anomalies of Patients with Joubert Syndrome
- Hang Bo Jeong, Se Hee Hwang, Ki Joong Kim, Yong Seung Hwang, Seung Cheol Kim, In-One Kim
- Clin Exp Pediatr. 1997;40(3):385-392. Published online March 15, 1997
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Purpose : Joubert syndrome is known tobean autosomal recessive disorder characterized by cerebellar vermian dysgenesis with many symptoms and variety of other malformations. We studied the relevant symptoms and various malformations of seven patients diagnosed as Joubert syndrome at our institution. Methods : Seven children with cerebellarvermian dysgenesis consistent with Joubert syndrome were included in ourstudy. Each child was diagnosed at the Seoul National University Children's... -
- Genital Mycoplasmasin the Newborn Infants: Colonization, Prevalence and Clinical Significance
- Yun Sil Chang, Sung Gwon Kim, Beyong Il Kim, Won Soon Park, Bo Hyun Yoon, Eui Chong Kim, Jung-Hwan Choi, Chong Ku Yun
- Clin Exp Pediatr. 1996;39(8):1084-1094. Published online August 15, 1996
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Purpose : The genital mycoplasmas: Ureaplasma urealyticum and Mycoplasma hominis have recently assumed an increasing importance as neonatal pathogens especially in preterm infants. The aim of the present study was to determine the prevalence of infections with these organisms in newborn infants who were admitted in Neonatal Intensive Care Unit(NICU) and who were suspected having infection in newborn nursery Methods : Sixty four inborns who... -
- The Usefulness of Clinical Scoring System as Prognostic Predictor in Neonatal Seizure
- Hyunmi Kim, Gyoung Hee Kim
- Clin Exp Pediatr. 1996;39(6):829-838. Published online June 15, 1996
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Purpose : Neonatal seizure is usually the presentation of underlying neurologic dysfunction rather than a disease and have high mortality and morbidity as sequalae. Therefore, the parameter predicting the neurologic prognosis is necessary. This study was performed to identify the usefulness of clinical scoring as predictor in neonatal seizure by analyzing outcomes. Methods : From 1982 to 1994, 101 neonates were admitted to Neonatal Intensive... -
- The Influence of the Use of Iodine during Perinatal Period on the Screening Test for Congenital Hypothyroidism
- Gyu Bum Cho, Dong Hwan Lee, Sang Jhoo Lee
- Clin Exp Pediatr. 1996;39(2):195-206. Published online February 15, 1996
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Purpose : This study was performed to detect the diseases of congenital hypothyroidism by the neonatal mass screening test early and to demonstrate the possible role of topical iodinated antiseptics(povidone-iodine, PVP-Ⅰ) on transient hyperthyrotropinemia in newborn infants. Methods : We performed neonatal screening tests for inborn errors of metabolism since 1985 by Guthrie test for PKU, maple syrup urine disease, histidinemia,... -
- Study on the Thyroid Function of Neonate Born to Mother with Hyperthyroidism
- Choong Ho Shin, Se Young Kim, Sei Won Yang, Jung Hwan Choi, Chong Ku Park
- Clin Exp Pediatr. 1996;39(1):106-114. Published online January 15, 1996
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Purpose : In newborns from mothers with Graves' disease, neonatal transient hyperthyroidism or hypothyroidism may develop early in life. We evaluated the incidence and prognosis of neonatal thyroid dysfunction in neonates born to mothers with hyperthyroidism during pregnancy. Methods : We measured blood T4, T3, TSH levels and TSH-R-Ab titer in 48 hyperthyroid mothers and their babies between 1988 and 1994. Results :... -
- Erratum
- Breast Feeding: A Neurobiologic Perspective
- Jan Winberg
- Clin Exp Pediatr. 1996;39(1):36-41. Published online January 15, 1996
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Breast-feeding(BF) failures are common in industrialized societies and can only partly be explained by social, psychologic, culturaland cognitive factors. The more profound causes remain unknown. This annotation presents clinical observations suggesting that several nursing care rituals in delivery rooms and maternity wards interfere with innate behavioural programs and consequently may disturb the unfolding feeding behaviour. Mother-infant interaction including BF depend on the activation of acomplex network... -
- Original Article
- Infantile Choledochal Cyst Presenting with Neonatal Cholestasis; Review of Anatomical and Clinical Aspect
- Jae Won Jeong, Jeong Kee Seo, Kwi Won Park, In Won Kim
- Clin Exp Pediatr. 1995;38(12):1629-1637. Published online December 15, 1995
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Purpose : Extrahepatic biliary atresia, neonatal hepatitis, Allagille syndrome are most common primary causes of the neonatal cholestasis. Infantile choledochal cyst is another primary disease presenting with neonatal cholestasis but its incidence is so low that it has been reported rarely. Choledochal cyst in infancy has been known to have clinically and anatomically different characteristics from ones after infancy. Thus... -
- Case Report
- Two Cases of Neonatal Adrenal Hemorrhage
- Kyeong Hye Jeong, Sung Suk Jeon, Ok Sung Jeong, Son Sang Seo, Jung Mee Kweon
- Clin Exp Pediatr. 1995;38(10):1411-1416. Published online October 15, 1995
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Neonatal adrenal hemorrhage is not uncommon due to its relative large size and vascularity, thus making it vulnerable to traumatic and asphyxial injuries. It뭩 etiology is unknown, but postulated etiologies include maternal diabetes, obstetric trauma, asphyxia, thrombocytopenia and coagulation defect. Clinical manifestations ate those of a paplable mass in the affected flank, anemia and jaundice. Hypoglycemia, hypotension and hypovolemia may... -
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- Original Article
- Changes of Serum Tumor Necrosis Factor-α and Interleukin-1β in the Sepsis of Neonates
- Mi Yeon Lee, Yeon Kyun Oh, Ji Hyun Cho
- Clin Exp Pediatr. 1995;38(10):1307-1314. Published online October 15, 1995
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Purpose : Cytokines have recently been identified as important endogenous mediators of the host immune response to bacterial infection. But little is clarify about serum levels of cytokines in neonatal sepsis. The aim of this study was to know the changes of the level of cytokines during neonatal sepsis, to compare the level of cytokines in gram negative and gram... -
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- Case Report
- Two Cases of Congenital TBG Deficiency
- In Seong Jo, Ha Joo Choi, Young Ah Lee, Woo Gap Chung, Youn Bok Chang
- Clin Exp Pediatr. 1995;38(5):697-701. Published online May 15, 1995
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We have experienced 4 and 5-week-old male neonates presented low T4 and normal TSH l-evel by filter paper mothod for neonatal screening, finally diagnosed typical TDG deficiency wit h TBG radioimmunoassay, paper electrophoresis, and autoradiography. Two neonates have ha d no specific complaints and lived well until now. Congenital TBG deficiency is an X chromosome linked inhcritant disorder characterized by l... -
- Four Cases of Benign Neonatal Convulsion
- Hwi Tae Kang, Heung Dong Kim, Young Ii Park, Churl Young Chung
- Clin Exp Pediatr. 1995;38(5):692-696. Published online May 15, 1995
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Benign neonatal convulsions are classified into benign idiopathic neonatal convulsions(fifth day fits) and benign familial neonatal convulsions. Benign familial neonatal convulsions occur mostly on the second and third days of life with f amily history of autosomal 4ominant trait. The prognosis is favourable but idiopathic epilepsy m ay occur in 5 percent of patients. Benign idiopathic neonatal convulsions ocurr around the fifth... -
- Erratum
- Clinical Evaluation of Unmarried Maternal Neonates Admitted to NICU
- Chang Weon Oh, Suk Hyun Lee, Kyoung Sim Kim, Ki Bok Kim
- Accepted January 1, 1970
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Purpose : This study was done to see whether neonates born to unmarried mothers have higher rates of prematurity, low birth weight, perinatal morbidity and mortality than normal married group. Methods : 88 neonates of unmarried mothers who were admitted in our NICU during the 5-year period from January 1987 through December 1991 were evaluated, and as the control gro-up served... -
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- Original Article
- Clinical Observation of Neonatal Sepsis according to Onset of Disease
- Young Chul Han, Soon Kyung Baik, Chang Sung Lim, Dong Jin Lee
- Clin Exp Pediatr. 1994;37(12):1676-1686. Published online December 15, 1994
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- Morphologic Changes of Lung Parenchymal Tissue in Neonatal Rat Pups under Chronic Hyperoxia
- Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
- Clin Exp Pediatr. 1994;37(8):1055-1064. Published online August 15, 1994
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We studied the effects of chronic hyperoxia (>95% oxygen for 14 days) in change of body weight, wet to dry ling weight ratio, and morphologic changes of lung tissue compared with that of room air (21% oxygen for 14 days) in Sprague-Dawley neonatal rat pups. The results were as follows: 1) In neonatal rat pups exposed to room air (normoxia group), body... -
- Normal Blood TSH, T4 Levels in Neonates as Determined by Screening Test
- In Ah Cha, Kwang Sin Kim, Kyoung Sim Kim, Young Wook Kim, Ki Bok Kim
- Clin Exp Pediatr. 1994;37(6):832-841. Published online June 15, 1994
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In 1,146 term neonates without perinatal problems who were born in kwangju Christian Hospital, blood TSH levels were measured by immunoradiometric assay. In 397 term neonates among them, blood T4 levels were measured by radioimmunoassay in same specimens. 1) In normal neonates aged 3~5days, 6~10days, 11~20days and 21~28days, the TSH levels were 8.885.21(meanSD), 9.44¡¾5.16, 9.69¡¾4.98, 11.963.75IU/ml and the T4 levels were... -
- Exchange Transfusion Using Percutaneous Femoral Vein Catheterization in Neonates: Comparison with Umbilical Vein Catheterization
- Song-Ja Kim, Hyang-Ok Woo, Seung-Hwan Kim, Mi-Ryeong Kim, Sun-Kyeong Sin, Hee-Shang Youn
- Clin Exp Pediatr. 1994;37(2):180-184. Published online February 15, 1994
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Traditionally umbilical vein has been used for exchange transfusion in neonates. This method is relatively safe and effective but with a few complications. So via percutaneous femoral vein catheters we tried exchange transfusion in 30 patients with neonatal hyperbilirubinemia admitted to GNUH from September 1990 to August 1992. Femoral vein catheterization succeeded in 2~3 trials. In all cases high bilirubin level... -
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